Health experts have warned that a new mutant strain of mpox has been discovered and it could be more infectious than current variants. The Africa Centre for Disease Control and Prevention (ACDCP) says the mutant Clade 1a mpox variant “has got high potential for higher transmissibility”
Dr Ngashi Ngongo, head of the ACDCPmpox incident management team, said the Clade 1a mutation is the same one found in Clade 1b, which has spread to the UK.Clade 1a could cause more severe disease than Clade 1b. Clade 1a can kill up to 10% of the people it infectsm where Clade 1b has a fatality rate of under 3.6%.
The mutation is calledAPOBEC3.
Dr Ngongo said: “We have seen a new variant of Clade 1a with APOBEC3 that has been detected, and unlike the old 1a variant, this one has got high potential for higher transmissibility.”
The World Health Organisation says mpox is still a ‘p ublic health emergency of international concern’ – the highest level of alert. It has been categorised as a serious threat since August as it spreads around the world.
Professor Salim Abdool Karim, chairman of the ACDCPEmergency Consultative Group said: “The outbreak remains uncontrolled, resources are insufficient, surveillance systems are weak, and health systems in many affected countries are struggling to contain the spread.”
The UKHSA is actively expanding access to mpox vaccines across England. Health officials announced the opening of 12 newmpoxvaccination sites across England last month.This expansion means that every region in the country is now able to offer vaccines to individuals at higher risk of contracting the virus. Previously, vaccines were only available to eligible people at 19 locations in London, Brighton and Manchester.
In October, England confirmed its first case of clade 1b mpox, a different strain from the one circulating at low levels in the UK since 2022. A month before this, the government announced the purchase of additional mpox vaccine doses to strengthen the country’s defences against the virus.
While the UK Health Security Agency (UKHSA) has confirmed the risk from mpox remains low, the aim is to increase and broaden access to these jabs.
“Mpox (previously known as monkeypox) is a rare infection most commonly found in parts of central and east Africa,” says Dr Michael Brady, national advisor for LGBT Health at NHS England, and consultant in Sexual Health and HIV at Kings College Hospital in London. “Mpox can be passed on from person to person through any close physical contact with mpox blisters or scabs.
“Once infected with mpox, it usually takes between five and 21 days for the first symptoms to appear.”
What are the symptoms of mpox?
“The first symptoms of mpox include a high temperature, headache, muscle aches and backache, swollen glands, shivering, exhaustion and joint pain,” says Brady. “A rash usually appears one to five days after the first symptoms and can be on any part of the body.”
Mpox can develop into more serious conditions, particularly in certain immunocompromised individuals because they are more likely to experience severe symptoms and complications.
“While most cases of mpox are mild, individuals with weakened immune systems, pregnant people, or those with underlying health conditions are at higher risk for severe complications,” says Dr Bruno Silvester Lopes, lecturer in microbiology at Teesside University, and researcher in pathogen spread and molecular epidemiology. “Potential complications include secondary infections, where bacterial infections can occur in lesions or blisters due to scratching or improper care.
“And, in rare cases, the infection can lead to systemic complications like sepsis.”
“Use over-the-counter pain relievers like acetaminophen or ibuprofen to reduce fever and alleviate body aches,” advises Lopes. “Keep the rash clean and covered to prevent infection and avoid scratching to reduce the risk of scarring and further infection.”
If symptoms flare up, it’s also important to stay hydrated and see your GP. “Drink plenty of fluids to stay hydrated, especially if experiencing fever or if the rash affects eating or drinking,” recommends Lopes. “Consult your GP to seek medical advice for specific treatment options, and to discuss the potential use of antiviral medications if symptoms are severe.
“And, most importantly, follow isolation guidelines to prevent spreading the virus to others until you are no longer contagious.”
“Mpox is caused by an infection with the mpox virus, so the mpox vaccine can give good protection against the virus. It is given as an injection,” explains Brady. “Most people will be offered two doses of the vaccine at least one month apart. Some people only need one dose.”
“You may be eligible for the mpox vaccine if you’re a man who has sex with men and have multiple partners, participate in group sex, or attend sex-on-premises venues,” says Brady. “Staff at these venues may also be eligible.
“If you have had contact with someone who has mpox, the mpox contact tracing team will contact you. They will check your risk of catching mpox and tell you if you need an mpox vaccine.”
The new vaccine centres are located in:
- Birmingham
- Nottingham
- Sheffield
- Sunderland
- Hull
- Leeds
- Liverpool
- Blackpool
- Southampton
- Bristol
- Exeter
- Hatfield
- Hertfordshire
This is in addition to 19 sites which are already operating in London, Greater Manchester and Brighton. “We expect the number of locations to increase further as more sites become available,” adds Brady.
“If you’re eligible you need to book an appointment – you can find a site listed on the NHS online site finder – some allow you to book online or you can contact the site directly,” explains Brady. “You do not need to be registered with a GP.
“If you meet the eligibility criteria please come forward and get protected. Simply search on the NHS website to find the vaccination site closest to you.”